Personalia
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Research Project
During my PhD studies I try to systematically investigate the dynamical nature of genomes. I will focus on a pathogenic group of organism, namely oomycetes, that comprises species with different life styles and host ranges. These species possess highly dynamical genomes with fast evolving gene families and novel combinations of functional domains. To tackle the challenges adhered to this genomes, I will try to combine our expertise on comparative genomics with experimental work of our collaborators, Francine Govers form Wageningen University ( Phytophthora Group ) and Guido van den Ackerveken from Utrecht University ( Plant-Microbe Genetics Group ). My PhD project is funded by the Center for BioSystems Genomics ( CBSG2012 ), a Centre of Excellence of the Netherlands Genomics Initiative.
Education
| 2008-present | PhD student, Theoretical Biology & Bioinformatics , Universiteit Utrecht, The Netherlands |
| 2008 | Diplom Biologe (Univ.), Bayerische Julius-Maximillians Universität Würzburg, Germany |
| 2006-2008 | Studies in Biology (advanced study period, main focus: bioinformatics, genetics, biochemistry), Bayerische Julius-Maximillians Universität Würzburg, Germany |
| 2005-2006 | Studies in Biology (advanced study period), Technische Universität Darmstadt, Germany |
| 2003-2005 | Studies in Biology (basic study period), Technische Universität Darmstadt, Germany |
Publications
Seidl MF, Van den Ackerveken G, Govers F & Snel B
Reconstruction of oomycete genome evolution identifies differences in evolutionary trajectories leading to present-day large gene families
Genome Biol. Evol. 4 (3): 199-211 (2012) doi:10.1093/gbe/evs003 [Supplementary data] [NBIC Press Release]
Stassen JHM, Seidl MF, Vergeer PWJ, Nijman IJ, Snel B, Cuppen E & Van den Ackerveken G
Effector identification in the lettuce downy mildew Bremia lactucae by massively parallel transcriptome sequencing
Mol. Plant Pathol. (Published Online 01.02.2012) doi:10.1111/j.1364-3703.2011.00780.x
Cabral A, Stassen JHM, Seidl MF, Bautor J, Parker JE & Van den Ackerveken G
Identification of Hyaloperonospora arabidopsidis transcript sequences expressed during infection reveals isolate-specific effectors
PLoS ONE 6(5): e19328 (2011) doi:10.1371/journal.pone.0019328
Seidl MF, Van den Ackerveken G, Govers F & Snel B
A domain-centric analysis of oomycete plant pathogen genomes reveals unique protein organization
Plant Physiology 155:628-644 (2011), doi:10.1104/pp.110.167841
Seidl MF & Schultz J
Evolutionary flexibility of protein complexes
BMC Evol. Biol. (2009), 9:155 doi:10.1186/1471-2148-9-155
Presentations
| 2011 | Comparative Genomics of Eukaryotic Microorganisms (EMBO Conference), San Feliu de Guixols (Spain), Oral Presentation, In silico identification of cis-regulatory motifs in the late blight pathogen Phytophthora infestans |
| 2011 | Fungal Genetics Conference, Asilomar (USA), Poster Presentation, Genome reconstruction of oomycete pathogens |
| 2011 | Oomycete Molecular Genetics Network Meeting, Asilomar (USA), Oral Presentation, Genome reconstruction of oomycete pathogens |
| 2011 | CBSG Summit, Wageningen (NL) Oral/Poster Presentation, Genome reconstruction of oomycete pathogens |
| 2010 | CBSG Summit, Wageningen (NL), Poster Presentation, Lineage specific gene expansion and evolution of virulance in plant pathgen genomes - A domain survey of oomycetes |
| 2008 | German Conference on Bioinformatics (GCB), Dresden (DE), Poster Presentation, Evolutionary flexibility of protein complexes. |