Utrecht University > Biology > Bioinformatics > Group members > Michael

Personalia

Michael F. Seidl
Name Michael F. Seidl, PhD
Position Research fellow (postdoc)
Research topics Comparative genomics and evolution of filamentous plant pathogens
Affiliations Bioinformatics group, Utrecht University
Address Padualaan 8
3584 CH Utrecht
the Netherlands
Location Room Z531
Phone +31 30 253 3419
Fax +31 30 251 3655
Email m.f.seidl(at)uu(dot)nl
LinkedIn Michael F. Seidl @ LinkedIn
Google scholar Citations Michael F. Seidl @ Google scholar
Curriculum vitae Michael F Seidl -- CV (pdf)

Research Interests

During my PhD studies I systematically investigated the dynamical nature of eukaryotic genomes. I focused on a pathogenic group of organism, namely oomycetes, that comprises species with different life styles and host ranges. These species possess highly dynamical genomes with fast evolving gene families and novel combinations of functional domains. To tackle the challenges adhered to this genomes, I combined our expertise on comparative genomics with experimental work of our collaborators, Francine Govers form Wageningen University ( Phytophthora Group ) and Guido van den Ackerveken from Utrecht University ( Plant-Microbe Genetics Group ). My PhD project was funded by the Center for BioSystems Genomics ( CBSG2012 ), a Centre of Excellence of the Netherlands Genomics Initiative.

I recently moved to a new position at Wageningen University where I continue to study the evolution of filamentous plant pathogens ( Bioinformatics Team) WordCloud

Curriculum Vitae

2012-present Visiting Scientist, Laboratory of Phytopathology, Wageningen University, The Netherlands
2012-present Research fellow (postdoc), Theoretical Biology & Bioinformatics , Universiteit Utrecht, The Netherlands
2008-2012 PhD, Theoretical Biology & Bioinformatics , Universiteit Utrecht, The Netherlands
2008 Diplom Biologe (Univ.), Bayerische Julius-Maximillians Universität Würzburg, Germany
2006-2008 Studies in Biology (advanced study period, main focus: bioinformatics, genetics, biochemistry), Bayerische Julius-Maximillians Universität Würzburg, Germany
2005-2006 Studies in Biology (advanced study period), Technische Universität Darmstadt, Germany
2003-2005 Studies in Biology (basic study period), Technische Universität Darmstadt, Germany

Publications

Seidl MF, Wang R-P, Van den Ackerveken G, Govers F & Snel B
Bioinformatic Inference of Specific and General Transcription Factor Binding Sites in the Plant Pathogen Phytophthora infestans
PLoS ONE 7(12): e51295. doi:10.1371/journal.pone.0051295

Seidl MF, Van den Ackerveken G, Govers F & Snel B
Reconstruction of oomycete genome evolution identifies differences in evolutionary trajectories leading to present-day large gene families
Genome Biol. Evol. 4 (3): 199-211 (2012) doi:10.1093/gbe/evs003 [Supplementary data] [NBIC Press Release]

Stassen JHM, Seidl MF, Vergeer PWJ, Nijman IJ, Snel B, Cuppen E & Van den Ackerveken G
Effector identification in the lettuce downy mildew Bremia lactucae by massively parallel transcriptome sequencing
Mol. Plant Pathol. (Published Online 01.02.2012) doi:10.1111/j.1364-3703.2011.00780.x

Cabral A, Stassen JHM, Seidl MF, Bautor J, Parker JE & Van den Ackerveken G
Identification of Hyaloperonospora arabidopsidis transcript sequences expressed during infection reveals isolate-specific effectors
PLoS ONE 6(5): e19328 (2011) doi:10.1371/journal.pone.0019328

Seidl MF, Van den Ackerveken G, Govers F & Snel B
A domain-centric analysis of oomycete plant pathogen genomes reveals unique protein organization
Plant Physiology 155:628-644 (2011), doi:10.1104/pp.110.167841

Seidl MF & Schultz J
Evolutionary flexibility of protein complexes
BMC Evol. Biol. (2009), 9:155 doi:10.1186/1471-2148-9-155

Presentations

2012 CBSG Summit, Wageningen (NL), Oral Presentation, An integrative probabilistic functional gene network in the plant pathogen Phytophthora infestans
2012 SMBE 2012, Dublin (IRL), Poster Presentation, An initial survey of the predicted protein-protein interaction network of the plant pathogen Phytophthora infestans
2012 CBSG Summit, Wageningen (NL), Poster Presentation, An initial survey of the predicted protein-protein interaction network of the plant pathogen Phytophthora infestans
2011 Comparative Genomics of Eukaryotic Microorganisms (EMBO Conference), San Feliu de Guixols (Spain), Oral Presentation, In silico identification of cis-regulatory motifs in the late blight pathogen Phytophthora infestans
2011 Fungal Genetics Conference, Asilomar (USA), Poster Presentation, Genome reconstruction of oomycete pathogens
2011 Oomycete Molecular Genetics Network Meeting, Asilomar (USA), Oral Presentation, Genome reconstruction of oomycete pathogens
2011 CBSG Summit, Wageningen (NL) Oral/Poster Presentation, Genome reconstruction of oomycete pathogens
2010 CBSG Summit, Wageningen (NL), Poster Presentation, Lineage specific gene expansion and evolution of virulance in plant pathgen genomes - A domain survey of oomycetes
2008 German Conference on Bioinformatics (GCB), Dresden (DE), Poster Presentation, Evolutionary flexibility of protein complexes.

Student projects

  • Phosphoproteomics in the plant pathogen Phytophthora infestans (Michael Seidl) (pdf)
  • Exploring whole genome duplications in eukaryotes - a case study on plant pathogenic oomycetes and the impact on adaptive radiation (Michael Seidl) (pdf)