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<h2> Research interests</h2> 
Vertebrate cells sample short peptides from endogenous
proteins, and present them to the immune system via MHC
class I molecules on the cell surface. T-cells scan the
presented peptides and need to discriminate foreign
(nonself) peptides from human (self) peptides.
We develop bioinformatics methods that can be used to identify antigenic regions in
basically any genome; these methods explained more in detail in <a 
href="http://bioinformatics.bio.uu.nl/kesmir/pMHC.html">
Epitope identification </a>. 

<p>

We apply these methods to: 
<LI> Study the evolution of antigen presentation and processing pathways. 
<LI> Study co-evolution of host and its pathogen using HIV-1 as a model system
<LI> Genetic associations of infectious diseases,
<LI> Identification of neo-antigens (mutated self antigens that are developed during cancer) 
<LI> Improve organ transplantation when a full matched donor is not available. 

<h3> Teaching, grants and other activities </h3> 

I am teaching <a href="http://www-binf.bio.uu.nl/BPA/index.html">Bioinformatic Pattern Analysis</a> 
and <a href="http://theory.bio.uu.nl/immbio"> ImmunoBiology </a> courses. Moreover, I am 
tutor for first year biology students. 


<h3>Contact</h3>
My full <a href="address.html">address</a>.

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